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The histone demethylase dKDM5/LID interacts with the SIN3 histone deacetylase complex and shares functional similarities with SIN3.
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The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.
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CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing.